NCT01422707

Effect of Short Term Adrenal Suppression on Androgen Overproduction in Overweight Girls With Androgen Excess

Effect of Short Term Adrenal Suppression on Androgen Overproduction in Overweight Girls With Androgen Excess (CBS003)

• Status: Withdrawn
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of Virginia · Academic / Other
• Sex: Female
• Age: 7 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

Short term hydrocortisone to test whether improves excess androgen production from adrenal gland and ovaries

Detailed description

This study will test whether short-term suppression of adrenal function can ameliorate androgen (male hormone) overproduction in overweight girls with androgen excess. The investigators hypothesize that one month of oral hydrocortisone administration will improve androgen levels in girls with adrenal androgen overproduction. Specifically, this intervention will improve androgen levels after adrenal stimulation testing with adrenocorticotropin hormone (ACTH).

Conditions

• Hyperandrogenemia
• Obesity
• Polycystic Ovary Syndrome

Interventions

Type	Name	Description
DRUG	Hydrocortisone	10 mg/m2/per day PO at bedtime (X4 weeks)

Timeline

• Start date: 2018-01-19
• Primary completion: 2018-07-17
• Completion: 2018-07-17
• First posted: 2011-08-24
• Last updated: 2018-07-19

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study