NCT01421706

Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects

Effects of Clopidogrel and Clarithromycin on the Disposition of Sibutramine and Its Active Metabolites M1 and M2 in Relation to CYP2B6*6 Polymorphism

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Inje University · Academic / Other
• Sex: Male
• Age: 19 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Effects of clopidogrel and clarithromycin on the oral disposition of sibutramine in healthy subjects

Detailed description

1\. Plasma concentrations of sibutramine and its two active metabolites after single oral dose of sibutramine were determined in Korean healthy male subjects with different CYP2B6 genotypes (CYP2B6\*1/\*1, \*1/\*6 and \*6/\*6), either alone or after four-day pretreatment with clopidogrel or clarithromycin.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Sibutramine-clopidogrel	Sibutramine-clopidogrel
DRUG	sibutramine-Clarithromycin	sibutramine-Clarithromycin

Timeline

• Start date: 2008-07-01
• Primary completion: 2009-07-01
• Completion: 2009-07-01
• First posted: 2011-08-23
• Last updated: 2012-09-18