Trials / Completed
CompletedNCT01419496
Study of Proteins in Promoting Chemotherapy Resistance in Samples From Patients With Acute Myeloid Leukemia
Identifying Stat3-Dependent Chemotherapy Resistance Pathways in Relapsed AML
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 40 (estimated)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 30 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about cancer and development of drug resistance in patients. PURPOSE: This research trial is studying proteins that may promote chemotherapy resistance in samples from patients with acute myeloid leukemia.
Detailed description
OBJECTIVES: * Investigate whether changes in prosurvival signaling occur by comparing activation of the signal transducer and activator of transcription-3 (Stat3) and Stat5 pathways in paired diagnostic and relapse samples. * Investigate changes in leukemia cell responses to extrinsic cues from the environment change, using a bone marrow stromal-cell co-culture model of chemotherapy resistance. OUTLINE: Cryopreserved samples are analyzed for Stat3 and Stat5 expression by flow cytometry and in vitro chemotherapy sensitivity.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | protein expression analysis | |
| OTHER | flow cytometry | |
| OTHER | laboratory biomarker analysis |
Timeline
- Start date
- 2011-09-01
- Primary completion
- 2016-05-01
- First posted
- 2011-08-18
- Last updated
- 2016-05-18
Source: ClinicalTrials.gov record NCT01419496. Inclusion in this directory is not an endorsement.