NCT01419275

Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 126 (actual)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya disease and stroke patients

Detailed description

In the early hours following large vessel occlusion, the ultimate severity of the stroke is largely determined by the ability of collateral flow networks to supply blood to ischemic tissue via circuitous routes that bypass the proximal clot. Robust collateral flow can improve response to thrombolytic therapy and decrease the risk of intracranial hemorrhage. Despite their central importance, collaterals during acute stroke are poorly understood, largely because assessment has required an invasive imaging test, cerebral angiography. This proposal assesses whether a noncontrast MRI perfusion technique, called arterial spin labeling (ASL), can yield important information about collateral flow.

Conditions

• Cerebrovascular Accident
• Moyamoya Disease

Interventions

Type	Name	Description
DRUG	Xenon contrast agent
DEVICE	Magnetic Resonance Imaging	Arterial spin label sequence for the purpose of measuring collateral flow

Timeline

• Start date: 2009-04-01
• Primary completion: 2013-11-01
• Completion: 2013-11-01
• First posted: 2011-08-18
• Last updated: 2017-08-30
• Results posted: 2017-08-30

Locations

1 site across 1 country: United States