NCT01418755

Study of Platelet-rich Plasma in Treating Patients With Tibiofemoral Cartilage Degeneration

Platelet-rich Plasma in Patients With Tibiofemoral Cartilage Degeneration

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Komzak Martin, M.D. · Academic / Other
• Sex: All
• Age: 31 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Recently an articular cartilage repair has been given much attention in the orthopaedic field. Cartilage regeneration capacity is very limited. Optimal approach seems to be a delivery of natural growth factors. Autologous platelet-rich plasma (PRP) contains proliferative and chemoattractant growth factors. The objective of the present study was to determine if PRP can increase tibiofemoral cartilage regeneration and improve knee function.

Detailed description

Fifty consecutive and strictly selected patients, affected by Grade II or III chondromalacia, underwent one year treatment (9 injections) with autologous PRP in a liquid form with 2,0 to 2,5-fold platelets concentration. Outcome measures included hte Lysholm, Tegner, IKDC, and Cincinnati scores. Magnetic resonance imaging was used to evaluate cartilage thickness and degree of degeneration.

Conditions

• Cartilage Degeneration

Interventions

Type	Name	Description
BIOLOGICAL	platelet rich plasma injection	The approximate 2.0 to 2.5-fold platelet concentration (taking into consideration the mean human blood platelet count of 200 000 /μl) was achieved in all specimens. Mean platelet concentration in PRP was 459 000 /μl (range, 407 000 /μl to 513 000 /μl).

Timeline

• Start date: 2009-01-01
• Primary completion: 2009-11-01
• Completion: 2011-07-01
• First posted: 2011-08-17
• Last updated: 2011-09-15

Locations

1 site across 1 country: Czechia