NCT01416051

Efficacy of Olibra: A 12 Week Controlled Trial

Efficacy of Olibra: A 12 Week Randomized Controlled Trial, and Review of Prior Studies

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 82 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Today's obesogenic environment, favors behavioral choices that lead to an excess of energy intake over expenditure, and consequently weight gain. Intervention strategies that harness the body's own appetite and satiety regulating signals could provide an effective means of countering excessive energy intake. The purpose of this study was to investigate whether a vegetable oil emulsion (Olibra) would result in weight loss that was associated with a reduction in food intake.

Detailed description

71 healthy subjects were enrolled (60 females, 11 males; Age: 18 - 60 years, BMI 25 - 40 kg/m2) in a two-phased, randomized, placebo-controlled, double-blind, parallel trial. During a 12-week period, Olibra was compared with a placebo (milk fat). Food intake testing was conducted on three days and anthropometric data was collected on 7 days. Key outcome measures were, body weight, body composition, energy intake, and appetite ratings.

Conditions

• Overweight
• Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Olibra	Fractionated palm oil and fractionated oat oil in the proportion of 95:5
OTHER	Placebo	100% milk fat

Timeline

• Start date: 2005-01-01
• Primary completion: 2006-11-01
• Completion: 2006-11-01
• First posted: 2011-08-12
• Last updated: 2015-12-18

Locations

1 site across 1 country: United States