NCT01414738

Hippocampal-Avoiding Whole Brain Irradiation With Simultaneous Integrated Boost for Treatment of Brain Metastases

Phase II Trial of Hippocampal-Avoiding Whole Brain Irradiation With Simultaneous Integrated Boost for Treatment of Brain Metastases

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The investigators hypothesize that avoidance of the hippocampal region with WBRT (Whole-Brain Radiotherapy ) may delay or reduce the onset, frequency, and/or severity of NCF (neurocognitive function) decline, as measured with clinical neurocognitive tools.

Detailed description

We propose to use conformal avoidance of the hippocampal region during whole brain radiotherapy to reduce the dose to the hippocampi, thereby putatively limiting the radiation-induced inflammation of the hippocampal region and subsequent alteration of the microenvironment of the neural progenitor cells

Conditions

• Brain Neoplasms, Adult, Malignant

Interventions

Type	Name	Description
RADIATION	Radiotherapy	Hippocampal-Avoiding Whole Brain Irradiation with Simultaneous Integrated Boost

Timeline

• Start date: 2011-10-18
• Primary completion: 2019-12-16
• Completion: 2019-12-16
• First posted: 2011-08-11
• Last updated: 2021-01-26
• Results posted: 2021-01-26

Locations

1 site across 1 country: United States