NCT01414595

Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer

Molecular Characterization of Lung Cancer: A Collaboration With the Cancer Genome Atlas Project (TGCA)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 248 (actual)
• Sponsor: Alliance for Clinical Trials in Oncology · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies tissue samples from patients with non-small cell lung cancer.

Detailed description

OBJECTIVES: * To identify and characterize single nucleotide variations (SNVs) in non-small cell lung cancer (NSCLC) specimens. * To identify and characterize structural variations in the genomes of NSCLC specimens. * To identify and characterize other genomic alterations including, but not limited to, expression profiling and methylation. OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide variations, structural variations in the genomes, and other genomic alterations including, but not limited to, gene expression profiling and methylation. Clinical data related to disease, treatment, and recurrence from each patient sample is also collected.

Conditions

• Lung Cancer

Interventions

Type	Name	Description
GENETIC	DNA analysis
GENETIC	DNA methylation analysis
GENETIC	RNA analysis
GENETIC	gene expression analysis
GENETIC	polymorphism analysis
OTHER	laboratory biomarker analysis
OTHER	medical chart review

Timeline

• Start date: 2012-03-01
• Primary completion: 2017-02-01
• First posted: 2011-08-11
• Last updated: 2017-06-27

Locations

11 sites across 1 country: United States