NCT01414530

Oral Contraceptive During Menopausal Transition

Effects of Oral Contraceptive on Muscle or Joint Ache in Women During Menopausal Transition

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (estimated)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: Female
• Age: 45 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Muscle or joint pain is one of the most common symptoms during menopausal transition. As this could be severe enough to affect social and daily life and to reduce quality of life, attentions should be paid about this. Although understanding of muscle or joint pain related to menopause is still insufficient, estrogen can play an important role. Previous studies have shown that estrogen protects cartilage in both animals and humans. However, perimenopause is different from postmenopause, in the point that estrogen is still secreted with a great fluctuation. Until now, no study has been performed to evaluate the effects of oral contraceptive on muscle or joint pain in women during menopausal transition. Moreover, since menopausal symptoms vary according to ethnicity and culture, a study in Korean population is necessary. Therefore, this randomized controlled trial was designed to evaluate the effects of oral contraceptive on muscle or joint pain in women during menopausal transition, compared to NSAID (non-steroidal anti-inflammatory drug).

Conditions

• Perimenopause

Interventions

Type	Name	Description
DRUG	oral contraceptive	ethinyl estradiol 0.03mg/levonorgestrel 0.15mg daily for 8 weeks
DRUG	NSAID	ibuprofen 200mg/arginine 185mg twice per day for 8 weeks

Timeline

• Start date: 2010-04-01
• Primary completion: 2014-06-01
• First posted: 2011-08-11
• Last updated: 2013-09-10

Locations

1 site across 1 country: South Korea