NCT01414010

Effects of Pre-, Pro- & Anti-biotics on Gut Microbiota

Effects of Mushroom Extract, S Boulardii and Amoxicillin on the Human Microbiome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Beth Israel Deaconess Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 39 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to compare and contrast the effects of a prebiotic (Trametes Versicolor), a probiotic (Saccharomyces boulardii) and an antibiotic (amoxicillin) on the gut microbiota of healthy volunteers. It is expected that treatment will result in the rapid and reproducible alterations in fecal microbiota that will spontaneously reverse in the weeks after treatment is discontinued.

Conditions

• Human Gut Microbiota

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Trametes versicolor extract	1,200 mg, 3 times daily on an empty stomach for 14 days
DIETARY_SUPPLEMENT	Saccharomyces boulardii	250 mg, 3 times daily on an empty stomach for 14 days
DRUG	Amoxicillin	250 mg 3 times daily at least 1 hour before meals for 7 days

Timeline

• Start date: 2011-08-01
• Primary completion: 2012-02-01
• Completion: 2012-02-01
• First posted: 2011-08-11
• Last updated: 2017-07-24
• Results posted: 2017-07-24

Locations

1 site across 1 country: United States