NCT01411371

Catheter Ablation Versus Medical Treatment of AF in Heart Failure

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Barts & The London NHS Trust · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Heart failure and atrial fibrillation (AF) often coexist, and each increases the morbidity and mortality associated with the other. The investigators hypothesized that restoration of normal sinus rhythm by catheter ablation is superior to medical treatment of AF in heart failure. This study randomizes patients with heart failure and persistent AF to medical treatment of AF or catheter ablation to restore sinus rhythm.

Conditions

• Atrial Fibrillation
• Heart Failure

Interventions

Type	Name	Description
PROCEDURE	Catheter ablation of persistent atrial fibrillation	Catheter ablation of AF as described previously by our group (e.g. Hunter et al, Heart 2010).
DRUG	Medical treatment alone	Medical treatment of persistent AF as 'normal care'. Patients are randomised to medical treatment alone for atrial fibrillation. Treatment will be as per current guidelines for persistent atrial fibrillation, with rate control as first line (using beta-blockers, calcium channel blockers and digoxin as indicated) and rhythm control as second line (using sotalol, dronedarone, or amiodarone as indicated). (Both groups will receive standard heart failure medication including angiotensin converting enzyme inhibitors, beta blockers, aldosterone antagonists, and diuretics as indicated).

Timeline

• Start date: 2005-03-01
• Primary completion: 2011-10-01
• Completion: 2011-10-01
• First posted: 2011-08-08
• Last updated: 2011-08-08

Locations

1 site across 1 country: United Kingdom