NCT01408979

Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia

Postpartum Prophylaxis With Short Course Magnesium Sulfate in Severe Preeclampsia: a Randomized Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Instituto Materno Infantil Prof. Fernando Figueira · Academic / Other
• Sex: Female
• Age: 11 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Magnesium sulfate is the ideal drug for seizures prophilaxis in preeclampsia. The ideal duration of this treatment after delivery is still to be established. The hypothesis is that in stable patients a shorter course of treatment is possible without prejudice to the mother.

Detailed description

Magnesium sulfate (MgSO4) is certainly the ideal drug for prevention and control of eclamptic seizures. However, there is no consensus on the appropriate duration of prophylaxis with this anticonvulsant postpartum.The objective of the present study is to compare effectiveness of 12 hours of magnesium sulfate versus 24 hours (standard treatment) in stable patients with preeclampsia.

Conditions

• Severe Preeclampsia

Interventions

Type	Name	Description
DRUG	Magnesium sulfate 12 hours	Magnesium sulfate, 1g/h, (10% solution), for 12 hours
DRUG	Magnesium sulfate 24 hours	Magnesium sulfate, 1g/h, (10% solution), for 24 hours

Timeline

• Start date: 2011-08-01
• Primary completion: 2011-12-01
• Completion: 2012-02-01
• First posted: 2011-08-03
• Last updated: 2012-08-22

Locations

1 site across 1 country: Brazil