NCT01407900

Effects of Chimeric Natriuretic Peptide Versus Placebo in Stable Heart Failure and Moderate Renal Dysfunction

A Human Physiologic Study to Evaluate the Renal and Neurohumoral Effects of Dual NPR-A and NPR-B Activation With a Novel Chimeric Natriuretic Peptide (CD-NP)in Subjects With Stable Chronic Heart Failure and Moderate Renal Dysfunction

• Status: Withdrawn
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: John A. Schirger · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Not accepted

Summary

The overall aim is to conduct a human physiologic study to assess the renal and neurohumoral effects of CD-NP vs placebo in older subjects with stable chronic systolic heart failure and moderate renal dysfunction.

Detailed description

The investigators will evaluate the renal and neurohumoral effects of dual receptor (NPR-A and NPR-B) activation with CD-NP. This is a clinically relevant patient population who is at increased risk of developing diuretic resistance during the treatment of HF exacerbations.

Conditions

• Heart Failure
• Renal Insufficiency

Interventions

Type	Name	Description
DRUG	CD-NP	CD-NP as a four hour infusion at 10 ng/kg/min IV
DRUG	5% Dextrose in Water	four hour infusion IV

Timeline

• Start date: 2014-01-01
• Primary completion: 2014-02-01
• Completion: 2014-02-01
• First posted: 2011-08-02
• Last updated: 2014-06-17