NCT01402115

A 12-week Human Trial to Compare the Efficacy and Safety of Polycan on Bone Metabolism

Efficacy and Safety Study of Polycan on Bone Metabolism

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Chonbuk National University Hospital · Academic / Other
• Sex: Female
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Beta-glucans are polysaccharides consisting of glucose residue jointed by beta linkage. They are found at a high level in the cell wall of fungi, yeast, oat, barley, bacteria, as well as various mushroom. Studies have reported that extract of mushroom (Pleurotus eryngii) can prevent the bone loss caused by estrogen deficiency. Furthermore, polycan (a purified β-glucan from Aureobasidium pullulans) has been reported to exhibit osteoporosis preventing effects. However, no investigation has been conducted on the effect of polycan on bone health in perimenopausal women. Therefore, in this study, we investigated the effect of polycan on biochemical markers of bone metabolism in Korean perimenopausal women.

Conditions

• Bone Health in Perimenopausal Women

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Polycan	polycan 150 mg/d for 12 weeks
DIETARY_SUPPLEMENT	Placebo	Placebo 150mg/d for 12 weeks

Timeline

• Start date: 2008-11-01
• Primary completion: 2009-02-01
• Completion: 2009-05-01
• First posted: 2011-07-26
• Last updated: 2012-10-12
• Results posted: 2012-10-05

Locations

1 site across 1 country: South Korea