NCT01398202

Dietary Supplementation With 25-hydroxyvitamin D3 in Older Adults

Comparison of the Bioefficacy of Oral 25-hydroxyvitamin D3 and Vitamin D3 Supplements on Vitamin D Status in Older Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 56 (actual)
• Sponsor: University College Cork · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate whether a supplement of 25-hydroxyvitamin D is five-times more potent in raising vitamin D status (as reflected by serum 25(OH)D) compared to an equivalent amount of vitamin D3 in older adults. It will entail a 10 week supplementation study during winter months.

Detailed description

The UK (McCance \& Widdowson) food composition tables suggests that 25-hydroxyvitamin D (which is present in some foods, albeit at very low concentrations, but which is also commercially available) may possess up to 5-times the activity of native vitamin D3 in food. Thus, in theory, each micogram of 25-hydroxyvitamin D consumed in the diet could boost vitamin D status up to five times most effectively compared to each microgram of native vitamin D in food. It is worth noting, however, that estimates of potency range from 2 to 5, depending on approach used, and that the real potency needs to be confirmed in a human study. This study aims to examine the biological activity of 25-hydroxyvitamin D (i.e., its potency relative to vitamin D3) as well as its effect on selected functional markers in a randomised, double-blind, human intervention trial in older adults.

Conditions

• Vitamin D Status as Reflected by Serum 25-hydroxyvitamin D

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	vitamin D3	20 micrograms per day for 10 weeks
DIETARY_SUPPLEMENT	25-hydroxyvitamin D3	7 microgram/day for 10 weeks
DIETARY_SUPPLEMENT	25-hydroxyvitamin D (20 microgram/day)	20 microgramday for 10 weeks
DIETARY_SUPPLEMENT	Placebo	0 ug vitamin D3/25-hydroxyvitamin D3/day for 10 weeks

Timeline

• Start date: 2011-01-01
• Primary completion: 2011-07-01
• Completion: 2011-09-01
• First posted: 2011-07-20
• Last updated: 2015-12-02

Locations

1 site across 1 country: Ireland