NCT01390181

The Effect of Losartan in Bicuspid Aortic Valve Patients

The Effect of Losartan Treatment on Matrix Metalloproteinase Levels and Outcomes in Bicuspid Aortic Valve Patients

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The specific aims of this study are to: * Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements \>40mm. * Assess the effect on MMP levels during treatment with losartan, an angiotensin II receptor blocking agent. * In the setting of losartan therapy for one year, evaluate the response of MMP levels in these patients, and clinical outcomes including effects on aortic growth rate

Conditions

• Bicuspid Aortic Valve
• Thoracic Aortic Aneurysm

Interventions

Type	Name	Description
DRUG	Cozaar	Angiotensin II Receptor Blocker

Timeline

• Start date: 2011-09-01
• Primary completion: 2014-01-01
• Completion: 2014-01-01
• First posted: 2011-07-08
• Last updated: 2017-04-14
• Results posted: 2017-04-14

Locations

1 site across 1 country: United States