NCT01390129

Remote Ischemic Preconditioning in Aortic Valve Surgery

Remote Ischemic Preconditioning in Aortic Valve Surgery (RIP-Valve)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: University Hospital, Angers · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

RIP-VALVE is a randomized, single blinded study that will test the hypothesis that remote ischemic preconditioning initiated before surgery reduces post-operative myocardial damage in aortic valve surgery. Infarct size will be determined by 72 hours area under curve of troponin-I.

Detailed description

The hypothesis tested in this research proposal is that remote ischemic preconditioning initiated immediately before aortic valve surgery reduces myocardial damage related to surgery.

Conditions

• Aortic Valve Stenosis

Interventions

Type	Name	Description
PROCEDURE	Control	Deflated blood pressure cuff placed on upper arm for 30min
PROCEDURE	Remote ischemic preconditioning	Blood pressure cuff placed on upper arm and inflated to 200 mmHg for 5 min and then deflated for 5 min. This cycle is initiated before aortic clamping and repeated 3 times in total

Timeline

• Start date: 2011-07-01
• Primary completion: 2012-10-01
• Completion: 2012-10-01
• First posted: 2011-07-08
• Last updated: 2012-10-24

Locations

1 site across 1 country: France