NCT01386918

Repetitive Transcranial Magnetic Stimulation for Refractory Auditory Hallucinations in Schizophrenia

A Randomized Double-Blind Sham-Controlled Trial of Transcranial Magnetic Stimulation for Refractory Auditory Hallucinations in Schizophrenia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 144 (actual)
• Sponsor: Centre for Addiction and Mental Health · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Studies using repetitive transcranial magnetic stimulation (rTMS) as a treatment for refractory auditory hallucinations (AH) in schizophrenia have shown promise. The majority of studies have examined the effect of low frequency left-sided stimulation (LFL) (i.e., 1 Hz) to the temporal parietal cortex (TPC). Priming stimulation (6 Hz) prior to LFL stimulation (hereby simply referred to as priming) has been shown to enhance the neurophysiological effects of LFL rTMS alone and, as such, may lead to greater attenuation of AH. Therefore, this study evaluated the efficacy of priming rTMS and LFL rTMS, compared to sham, applied to the TPC in patients with schizophrenia experiencing refractory auditory hallucinations (AH).

Conditions

• Refractory Schizophrenia

Interventions

Type	Name	Description
DEVICE	repetitive Transcranial Magnetic Stimulation	The treatment involves the administration of a magnetic field applied to a specific area of the brain.

Timeline

• Start date: 2004-02-01
• Primary completion: 2009-01-01
• Completion: 2009-01-01
• First posted: 2011-07-01
• Last updated: 2012-01-06

Locations

1 site across 1 country: Canada