NCT01384279

The Therapeutic Effects of Topiramate and Metformin on Second Generation Antipsychotics-induced Obesity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Beitou Armed Forces Hospital, Taipei, Taiwan · Other Government
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The primary aim of the study is to investigate the efficacy of metformin and topiramate on second-generation antipsychotic-induced obesity. The secondary domain we look at is the adverse effects of both drugs. The investigators hypothesize that metformin and topiramate are effective in treating obesity induced by second-generation antipsychotics.

Conditions

• Obesity

Interventions

Type	Name	Description
DRUG	metformin, topiramate	metformin 250 mg/d is gradually increased to 1000 mg/d over four weeks, and topiramate 50 mg/d is gradually increased to 200 mg/d over four weeks

Timeline

• Start date: 2011-05-01
• Primary completion: 2011-12-01
• Completion: 2012-01-01
• First posted: 2011-06-29
• Last updated: 2012-02-24

Locations

1 site across 1 country: Taiwan