Trials / Completed
CompletedNCT01380626
Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients
Effects of Exercise Training on Quadriceps Gene Expression in COPD-patients in Comparison to Alpha-1-Antitrypsin-deficiency-patients
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 20 (actual)
- Sponsor
- Schön Klinik Berchtesgadener Land · Academic / Other
- Sex
- All
- Age
- 40 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
Chronic Obstructive Pulmonary Disease (COPD)-patients (caused by smoking-level) and Alpha-1-Antitrypsin-deficiency patients showed different developments during rehabilitation in regard to improvement of 6-minute-walking distance. The aim of this study is to investigate differences between training adaptations in COPD-patients and Alpha-1-deficiency patients. Both groups take part in a standardized multimodal 3-week-rehabilitation with strength and endurance training. In addition to conventional diagnostic procedures, muscle biopsies from the M. vastus lateralis will be conducted before and after rehabilitation program followed by biochemical, histochemical and immunohistochemical analysis of the probes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | exercise training | strength and endurance training, 5 time per week. |
Timeline
- Start date
- 2010-02-01
- Primary completion
- 2013-03-01
- Completion
- 2013-04-01
- First posted
- 2011-06-27
- Last updated
- 2013-12-17
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT01380626. Inclusion in this directory is not an endorsement.