NCT01376882

Cognitive and Cerebral Blood Flow Effects of 2-week Caffeine Abstinence or Maintenance

Behavioural and Cerebral Haemodynamic Effects of Caffeine Withdrawal and Caffeine Administration Following 2-week Maintenance or Abstinence

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (actual)
• Sponsor: Northumbria University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the effects of 2 weeks caffeine abstinence as compared to 2 weeks caffeine maintenance (300mg per day)on cognition and mood. Cerebral blood flow effects will also be assessed in a subset of participants. The role of caffeine abstinence/maintenance in the acute effects of caffeine will also be explored.

Detailed description

The current randomised, placebo-controlled, double-blind, parallel groups study aims to explore the behavioural effects of 2-weeks caffeine abstinence as well as establishing the role of abstinence in the effects of caffeine administration by administering caffeine or placebo to those in a state of chronic and acute abstinence. This research also aims to explore, in a subset of participants, the cerebral blood flow effects of caffeine abstinence and caffeine administration using Near Infrared Spectroscopy (NIRS). Cerebral blood flow will be measured both at rest and during performance of cognitive tasks.

Conditions

• Cognitive Function
• Mood
• Cerebral Haemodynamics
• Caffeine Withdrawal

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo	Inert placebo containing silica powder CAB-O-SIL-M-5Pharma (Pharmaceutical grade)CABOT GmbH. 1 Size 0 capsule 3 times a day for 14 days and 1 size 0 capsule on day 15.
DIETARY_SUPPLEMENT	Caffeine and Placebo	100 mg Caffeine capsules 3 times per day for 14 days and 1 size 0 capsule of inert placebo containing silica powder CAB-O-SIL-M-5Pharma (Pharmaceutical grade)CABOT GmbH on day 15.
DIETARY_SUPPLEMENT	Placebo and Caffeine	Inert placebo capsules containing silica powder CAB-O-SIL-M-5Pharma (Pharmaceutical grade)CABOT GmbH, 1 Size 0 capsule 3 times a day for 14 days and a 100mg caffeine capsule on day 15.
DIETARY_SUPPLEMENT	Caffeine	Capsule containing 100 mg caffeine, one 3 times a day for 14 days and then one capsule on day 15.

Timeline

• Start date: 2011-03-01
• Primary completion: 2013-03-01
• Completion: 2013-03-01
• First posted: 2011-06-20
• Last updated: 2013-03-29

Locations

1 site across 1 country: United Kingdom