NCT01373866

Multimodal MRI-guided rTMS to Treat Refractory Hallucinations

Multimodal MRI-guided Repetitive Transcranial Magnetic Stimulation to Treat Drug-resistant Hallucinations: a Randomized Control Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 85 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 13 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

* The efficacy of neuro-navigated rTMS for patients with schizophrenia suffering from drug-resistant multisensory hallucinations will be tested by the implementation of a double-blind randomized controlled trial (RCT) * This study will use a combination of different MRI modalities (fMRI and DTI) to define with precision rTMS brain-targets in the case of multisensory hallucinations * The investigators anticipate that multimodal MRI-guided rTMS will allow a significant improvement in the efficacy of neuromodulation treatment of refractory hallucinations

Conditions

• Hallucinations
• Schizophrenia
• Perceptual Disorders

Interventions

Type	Name	Description
DEVICE	MagPro X100 repetitive Transcranial Magnetic Stimulation	Target defined using both fMRI during hallucinations occurence and tractography. Parameters: 1 Hz/ 100% of the Motor Threshold/ 10 sessions (2/ day over 5 days)/ 1200 pulses/ session
DEVICE	MagPro X100 repetitive Transcranial Magnetic Stimulation	Target: T3-P3 (10-20 EEG international System). Parameters: 1 Hz/ 100% of the Motor Threshold/ 10 sessions (2/ day over 5 days)/ 1200 pulses/ session

Timeline

• Start date: 2010-11-15
• Primary completion: 2022-02-11
• Completion: 2022-02-11
• First posted: 2011-06-15
• Last updated: 2025-12-26

Locations

2 sites across 1 country: France