NCT01372293

71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women

17-hydroxysteroid Dehydrogenase Type 5 Gene Polymorphism (71A/G HSD17B5 SNP) and Effects of Oral Contraceptive Pill on Hirsutism, Androgens and Metabolic Profile in Non-obese PCOS Women: a Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 49 (actual)
• Sponsor: Federal University of Rio Grande do Sul · Academic / Other
• Sex: Female
• Age: 15 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A\>G) with polycystic ovary syndrome (PCOS) and hyperandrogenemia has been suggested in previous studies. Given the role of 17b-HSD5 in androgenic metabolism producing testosterone from precursors, the investigators hypothesis is that women with PCOS and with the variant allele G have a poor response on hirsutism and on hormonal and metabolic variables after oral contraceptive pill (OCP) treatment for 6 months.

Conditions

• Polycystic Ovary Syndrome

Interventions

Type	Name	Description
DRUG	oral contraceptive pill	ethinyl oestradiol 20ug plus gestodene 75ug during 6 cycles

Timeline

• Start date: 2005-01-01
• Primary completion: 2008-01-01
• Completion: 2010-12-01
• First posted: 2011-06-13
• Last updated: 2011-09-12