NCT01369186

Drug Drug Interactions of Aspirin and P2Y12-inhibitors

Drug Drug Interactions of Antiplatelet Drugs and Morphine

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 95 (actual)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Study Objective: To investigate potential drug-drug interactions (pharmacokinetics and pharmacodynamics) of morphine and antiplatelet drugs (aspirin, clopidogrel, prasugrel, ticagrelor)

Detailed description

Rationale: Opiates reduce the intestinal resorption of orally administered drugs such as paracetamol. Because morphine is often injected to relieve pain in patients with myocardial infarction, it is of particular interest if morphine may decrease the rate of absorption of antiplatelet drugs. Results of this study will provide essential information for the use of morphine and antiplatelet drugs in clinical practice, in particular in myocardial infarction.

Conditions

• Drug Interaction Potentiation
• Myocardial Infarction

Interventions

Type	Name	Description
DRUG	Morphine	i.v. bolus injection
DRUG	Placebo	i.v. bolus injection

Timeline

• Start date: 2011-05-01
• Primary completion: 2015-01-01
• Completion: 2015-01-01
• First posted: 2011-06-08
• Last updated: 2017-03-27

Locations

1 site across 1 country: Austria