NCT01367691

Cardiac MR (CMR) in Cardiac Resynchronization Therapy Non-responders

Cardiac MR (CMR) in Cardiac Resynchronization Therapy (CRT) Non-responders: Therapy Optimization by Means of Tissue Characterization, Hemodynamic Analysis and Analysis of Myocardial Activation

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 1 (actual)
• Sponsor: University Hospital, Bonn · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cardiac MR (CMR) will be used to assess myocardial activation and hemodynamics in patients with CRT. Goals are to demonstrate that * differences in Left ventricle (LV)- right ventricle (RV) pacing delays cause differences in myocardial activation * differences in LV-RV pacing delays cause differences in LV/RV hemodynamics and to use these data to optimize CRT.

Detailed description

CMR will be performed in patients under CRT who are currently not responding to CRT. Different LV-RV delays will be programmed during CMR and LV function and different dyssynchrony parameters will be assessed. Results will be used to determine the optimal LV-RV delay, and CRT-devices will be reprogrammed accordingly. Improvement in NYHA-class/conversion to therapy responder will be determined clinically after 3 months.

Conditions

• Heart Failure

Interventions

Type	Name	Description
DEVICE	CRT reprogramming (Medtronic CRT)	CRT devices will be reprogrammed according to CMR analysis

Timeline

• Start date: 2011-06-01
• Primary completion: 2013-12-01
• Completion: 2013-12-01
• First posted: 2011-06-07
• Last updated: 2014-02-03

Locations

1 site across 1 country: Germany