NCT01366924

Essential Amino Acids Supplementation and Muscle Protein Synthesis

The Effect of Amino Acid Supplementation on Skeletal Muscle Protein Turnover Following Endurance Exercise

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: United States Army Research Institute of Environmental Medicine · Federal
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The modern warfighter faces numerous physiological challenges including sleep deprivation, sustained intense physical activity, and caloric restriction, the combined effects of which may result in the loss of lean body mass and decreased physical performance. Dietary interventions may help preserve lean body mass and facilitate recovery from periods of intense physical demand. For example, dietary strategies that increase amino acid availability have been shown to stimulate protein synthesis in skeletal muscle following resistance exercise. Because military tasks also incorporate endurance exercise components, studies regarding the effects of increasing dietary amino acids following endurance exercise are warranted. The objectives of this study are to characterize the effect of endurance exercise on protein synthesis and breakdown as well as the ability of an essential amino acid supplement to influence skeletal muscle protein metabolism and its cellular and molecular regulation following endurance exercise.

Conditions

• Muscle Loss
• Muscle Anabolism

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Essential Amino Acids	10 Gram Essential Amino Acid solutions with different leucine contents consumed during two identical endurance exercise trials
OTHER	Endurance exercise	60 minute endurance exercise session

Timeline

• Start date: 2007-05-01
• Primary completion: 2010-07-01
• Completion: 2010-07-01
• First posted: 2011-06-06
• Last updated: 2017-07-21

Locations

2 sites across 1 country: United States