NCT01366768

Gut Hormones After Oral Versus Intravenous Amino Acids

Release of Gut Hormones After Oral Versus Intravenous Amino Acids

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Lund University · Academic / Other
• Sex: Male
• Age: 20 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The study hypothesis is that gut hormones are released after oral but not intravenous amino acids which result in stimulation of insulin secretion.

Detailed description

Amino acid mixture is given orally or intravenously to match total concentrations of amino acids in healthy subjects. Samples are taken regularly for 300 min after administrations. Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and glucagon.

Conditions

• Normal Non-fluency

Interventions

Type	Name	Description
OTHER	Oral amino acid mixture	Amino acid mixture 2,93 ml/kg
OTHER	Intravenous amino acid administration	Amino acid mixture 2,93 ml/kg

Timeline

• Start date: 2011-05-01
• Primary completion: 2012-09-01
• Completion: 2012-09-01
• First posted: 2011-06-06
• Last updated: 2012-10-10

Locations

1 site across 1 country: Sweden