NCT01365195

Effect of Ketamine on Postoperative Clinical Outcomes

Intraoperative Ketamine Administration in Colorectal Surgery: Effect on Postoperative Clinical Outcomes

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Cedars-Sinai Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research is to evaluate the effectiveness of ketamine as an analgesic adjuvant in decreasing the narcotic (opioids) analgesics during surgery, on pain management and on the later recovery after surgery in patients undergoing colorectal surgery.

Detailed description

Adjuvant is a drug that has few or no pharmacological effects by itself, but may increase the effectiveness or strength of other drugs when given at the same time.

Conditions

• Colorectal Surgery

Interventions

Type	Name	Description
DRUG	Placebo	Loading and Infusion: Saline at infusion rate calculated and adjusted for weight to match ketamine bolus-infusion rate
DRUG	Ketamine high-dose	Loading: 1 mg/Kg Infusion: 10 mcg/kg/min
DRUG	Ketamine low-dose	Loading: 0.5 mg/Kg Infusion: 5 mcg/kg/min

Timeline

• Start date: 2011-05-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2011-06-03
• Last updated: 2022-03-02
• Results posted: 2022-03-02

Locations

1 site across 1 country: United States