NCT01361971

Hyperbaric Oxygen Treatment Ameliorates Insulin Resistance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Adelaide · Academic / Other
• Sex: Male
• Age: 45 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have preliminary evidence showing that hyperbaric oxygen therapy rapidly increases insulin sensitivity in humans. This requires confirmation in a larger population, and with this study the investigators will also test for mechanisms how this occurs. The investigators suspect that modulation of hypoxia and stress response proteins following changes in tissue oxygenation may contribute to these improvements. This study has the potential to yield new and important insights into the insulin resistance in obesity.

Conditions

• Obesity
• Type 2 Diabetes

Interventions

Type	Name	Description
PROCEDURE	Hyperbaric Oxygen Treatment	Participants will undergo 4 treatments of hyperbaric oxygen. Each treatment consists of 90 minutes compression at 2 atmospheres of pressure, with 30 minutes decompression back to 1 atmosphere, during this time, patients will be treated with 100% Oxygen delivered via a hood system.

Timeline

• Start date: 2011-04-01
• Primary completion: 2013-01-01
• Completion: 2013-01-01
• First posted: 2011-05-27
• Last updated: 2013-09-19

Locations

1 site across 1 country: Australia