NCT01360398

Infectious Pathogens in Acute Respiratory Illness in Adults and Elderly

Contribution of Infectious Pathogens to Acute Respiratory Illness in Adults and Elderly

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 127 (actual)
• Sponsor: GlaxoSmithKline · Industry
• Sex: All
• Age: 40 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to generate epidemiological data to further explore determinants of Chronic Obstructive Pulmonary Disease (COPD) and the contribution of bacterial and viral pathogens to Acute Exacerbation of COPD (AECOPD) episodes.

Conditions

• Respiratory Disorders

Interventions

Type	Name	Description
PROCEDURE	Blood sample	Blood samples will be collected from all patients at enrolment, at follow-up visits, at exacerbation visits, and during the final visit.
PROCEDURE	Sputum sample	Sputum will be collected from all patients at enrolment, at monthly follow-up visits, at exacerbation visits, and during the final visit. Sputum will be obtained by spontaneous expectoration or induced by stimulation according to standard methods.
PROCEDURE	Nasopharyngeal swab	Nasopharyngeal swabs will be collected from all patients at enrolment and from a subcohort of 30 patients at monthly follow-up visits and at exacerbation visits during the first year.
PROCEDURE	Urine sample	Urine samples will be taken at enrolment and exacerbation visits from all subjects and from the same subcohort of 30 patients providing nasopharyngeal swabs, at monthly follow-up visits during the first year.
PROCEDURE	End tidal breath sample	Breath samples will be collected from all patients at enrolment, at follow-up visits (monthly), at exacerbation visits, and during the final visit.
OTHER	Data collection	Patient interview, diary cards review and questionnaires completion
OTHER	Tests	Urine pregnancy test, chest CT-scan, lung function testing and 6-min walk test

Timeline

• Start date: 2011-06-30
• Primary completion: 2014-06-27
• Completion: 2014-06-27
• First posted: 2011-05-25
• Last updated: 2019-02-15
• Results posted: 2019-02-15

Locations

1 site across 1 country: United Kingdom