NCT01360073

Association Between Low Dose Acetylsalicylic Acid (ASA) and Proton Pump Inhibitors and Risk of Acute Myocardial Infarction or Coronary Heart Disease Death

Association Between Low Dose Acetylsalicylic Acid (ASA) and Proton Pump Inhibitors and Risk of Acute Myocardial Infarction or Coronary Heart Disease Death - Nested Case Control Analyses in a Cohort of Patients With Acute Serious Coronary Heart Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 42,542 (actual)
• Sponsor: AstraZeneca · Industry
• Sex: All
• Age: 50 Years – 84 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to estimate the risk of myocardial infarction (MI)/coronary death associated with use of monotherapy low dose ASA (single antiplatelet) as well as concomitant use of monotherapy low dose ASA and proton pump inhibitors (PPIs) in patients with serious coronary heart disease using two UK primary care databases.

Detailed description

Number of Anticipated Subjects: In case-control analysis: 10.000-15.000 participants

Conditions

• Nonfatal Myocardial Infarction
• Coronary Death

Timeline

• Start date: 2011-07-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2011-05-25
• Last updated: 2012-11-14

Locations

2 sites across 2 countries: Spain, Sweden