NCT01360047

Association Between Low Dose Acetylsalicylic Acid (ASA) and Proton Pump Inhibitors and Risk of Acute Myocardial Infarction or Coronary Death

Association Between Low Dose Acetylsalicylic Acid (ASA) and Proton Pump Inhibitors and Risk of Acute Myocardial Infarction or Coronary Heart Disease Death - Nested Case Control Analyses in a Cohort of First-time Users of Low Dose ASA for Secondary Prevention of Cerebrovascular and Cardiovascular Outcomes.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 39,513 (actual)
• Sponsor: AstraZeneca · Industry
• Sex: All
• Age: 50 Years – 84 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to estimate the risk of myocardial infarction (MI)/coronary death associated with use of monotherapy low dose ASA (single antiplatelet) as well as concomitant use of monotherapy low dose ASA and proton pump inhibitors (PPIs) in first- time users of low dose ASA for secondary prevention using a UK primary care database.

Detailed description

Number of Anticipated Subjects: In case-control analysis 5.000-10.000

Conditions

• Nonfatal Myocardial Infarction
• Coronary Death

Timeline

• Start date: 2011-06-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2011-05-25
• Last updated: 2012-11-14

Locations

1 site across 1 country: Spain