NCT01358890

Low-Carbohydrate Diet Intervention on Body Weight

Effect of Low-Carbohydrate or Restricted-Calories Diet on Body Weight

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Chinese Academy of Sciences · Other Government
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

* The primary aim of this study is to determine the adherence of low- carbohydrate among Chinese. * Then compare the effect of low-carbohydrate and traditional Chinese but restricted-calories diet on weight loss and metabolic traits.

Detailed description

Obesity is a well established risk factor for type 2 diabetes mellitus, hypertension, dyslipidemia and cardiovascular disease. Along with rapid nutritional and lifestyle transition featured as increased energy dense diet intake and reduced physical activity, the prevalence of obesity has reached epidemic level and affected more than 70 million Chinese adults nowadays. Previous studies suggested that low-carbohydrate diet was an effective and safe way to lose weight and had potential benefit on lipids profiles. However, it is still unknown whether this diet can be feasible to control the epidemic of obesity and its related metabolic diseases among Chinese, whose carbohydrate consumption contribute approximately 55% of total energy intake. Therefore, the aim of this pilot study is to investigate the adherence and effectiveness of two weight-loss diets among Chinese. This will be a randomized, controlled clinical trial. A total of 50 overweight or obese nurse assistants will be randomly assigned to receive a low-carbohydrate diet or a traditional high-carbohydrate Chinese but restricted-calories diet for 12 weeks. The adherence of study protocol and effects of the two diets on body weight, waist circumference, body fat, fasting glucose and lipid profile will be evaluated.

Conditions

• Over Weight
• Obesity

Interventions

Type	Name	Description
OTHER	low carbohydrate diet	Dietary carbohydrate diet was restricted to 20 gram/day within the first week, then increase gradually to 120 gram/day
OTHER	Calories restricted diet	Total energy intake is restricted to 1200 kcal/day for women. Energy from carbohydrate, protein and fat will be kept to approximate 55%, 20% and 25%, respectively. Moreover, saturated fat and dietary cholesterol are restricted to at most 10% energy and 300 mg/day, respectively

Timeline

• Start date: 2011-05-01
• Primary completion: 2011-08-01
• Completion: 2011-08-01
• First posted: 2011-05-24
• Last updated: 2012-02-28

Locations

1 site across 1 country: China