NCT01351337

Functional Monitoring for Motor Pathway in Brain Tumor Surgery Within Eloquent Area

Clinical Efficiency of Motor Pathway Mapping Using Diffusion Tensor Imaging Tractography and Intraoperative Subcortical Stimulation in Cerebral Glioma Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: Huashan Hospital · Academic / Other
• Sex: All
• Age: 6 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Resection of brain tumors in eloquent areas involves the risk of postoperative motor deficits. For brain tumors within or adjacent to the eloquent area, maximizing tumor resection while preserving motor function is crucially important.we used DTI-based tractography to visualize the spatial relationship between brain lesions and the nearby pyramidal tract(PT) in patients with malignant brain tumors and confirmed functional connections of the illustrated PT by direct electrical stimulation. We evaluated the reliability of DTI-based tractography for PT mapping using intraoperative subcortical stimulation ) and the usefulness of the combination of two techniques.

Detailed description

Adverse effects caused by electrical stimulation during the operation were recorded. All subjects adopted early postoperative MRI examinations (within 3 days) to evaluate both the extent of tumor resection and the integrity of the PTs. Muscle strength was assessed preoperatively and postoperatively.The Karnofsky Performance Scale (KPS) was adopted for grading functional status at the 6-month evaluation. Further tumor progression interval and survival analysis was conducted for each subject with high-grade glioma (HGG)

Conditions

• Glioma, Motor Pathway

Interventions

Type	Name	Description
PROCEDURE	diffusion tensor tractography neuronavigation and intraoperative subcortical stimulation	All of the patients underwent tumor resection assisted with combined use of Diffusion tensor tractography-integrated functional neuronavigation and intraoperative subcortical stimulation

Timeline

• Start date: 2008-10-01
• Primary completion: 2009-06-01
• Completion: 2013-02-01
• First posted: 2011-05-10
• Last updated: 2015-04-20
• Results posted: 2015-04-20

Locations

1 site across 1 country: China