NCT01350908

Study of Circulating Tumoral DNA in Ovarian Cancer

Development and Validation of a Circulating Tumor DNA Detection Technique in Patients With Ovarian Cancer

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Institut Curie · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Circulating tumor DNA detection and quantification in patients with ovarian cancer.

Detailed description

Technique development: In a first step, the different available techniques will be evaluated for specificity and sensibility using serial dilutions of cell lines with or without TP53 mutation. Validation: The tumor DNA detection rate will be estimated from patient's blood with ovarian cancer. The investigators will study 25 patients to obtain at least 15 patients bearing a TP53 mutation that could be characterized in the primitive tumor or metastasis. With those 15 patients, the investigators will determine the most sensitive technique and the best cost/efficiency ratio.

Conditions

• Ovarian Cancer

Interventions

Type	Name	Description
OTHER	Blood sampling	30mL of peripherical blood will be collected specially for the study. It's an additional blood sampling compare to the normal follow up of the patient.

Timeline

• Start date: 2011-04-01
• Primary completion: 2015-01-01
• Completion: 2015-12-01
• First posted: 2011-05-10
• Last updated: 2024-01-31

Locations

1 site across 1 country: France