NCT01350284

The Effect of Natural Food Flavourings on Gastrointestinal and Cardiovascular Physiological Responses.

Effect of Cinnamon on Gastric Emptying, Arterial Stiffness, Postprandial Lipaemia, Glycaemia, and Appetite Responses to High-fat Breakfast

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: University of Limerick · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether 3 g cinnamon was sufficient to delay the gastric emptying rate of a high-fat solid meal and subsequently reduce postprandial blood glucose and lipid responses, oxidative stress, arterial stiffness and satiety responses in a healthy adult population.

Detailed description

Cinnamon has been shown to delay gastric emptying (GE) of a high-carbohydrate meal and reduce postprandial glycaemia in healthy adults. However, it is dietary fat which is implicated in the etiology and is associated with obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD). We aimed to determine the effect of 3 g cinnamon on GE, postprandial lipemic and glycemic responses, oxidative stress, arterial stiffness, as well as appetite sensations and subsequent food intake following a high-fat (HF) meal. The effect of acute oral administration of 3 g cinnamon on gastric emptying of a high-fat pancake test meal and subjective appetite sensations by visual analogue scale will be measured for six hours postprandially. During this time course, measurements of postprandial lipemic, glycemic, oxidative stress and arterial stiffness responses will be collected. Subsequently, food intake will be measured using an ad libitum buffet meal. The study will be conducted in a randomized, placebo-controlled, single-blinded manner in 9 healthy subjects.

Conditions

• Gastric Emptying
• Diabetes Mellitus

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Cinnamon	acute oral administration of 3 g cinnamon
DIETARY_SUPPLEMENT	Placebo control	3 g wheat flour (placebo)- separated by 28 days from cinnamon intervention

Timeline

• Start date: 2009-06-01
• Primary completion: 2009-07-01
• Completion: 2010-03-01
• First posted: 2011-05-09
• Last updated: 2011-05-09

Locations

1 site across 1 country: Ireland