NCT01349387

Effect of Treatment With Metformin in Type 2 Diabetes Patients on Alternative Genes Splicing

Effect of Treatment With Metformin in Type 2 Diabetes Patients on Alternative Genes Splicing Whose Maturation Depends on the Protein HuR, Including Gene Encoding Insulin Receptor

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Main objective : Show that treatment with metformin in patients with type 2 diabetes has an effect on alternative splicing of the insulin receptor. Secondary objective : demonstrate that the effect on the ratio A/isoform B isoform with discontinuation of treatment with metformin can be réversé by the resumption of metformin treatment.

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
DRUG	Metformin	After inclusion in the study to J0, metformin treatment will be interrupted between J1 and J30, replaced by Januvia 100 mg/day dose, then resumed at J31.

Timeline

• Start date: 2011-05-01
• Primary completion: 2011-11-01
• Completion: 2012-01-01
• First posted: 2011-05-06
• Last updated: 2012-02-09

Locations

1 site across 1 country: France