NCT01349114

Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic Subjects

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: All
• Age: 19 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The study will evaluate the effects of the direct renin inhibitor, aliskiren, on flow-mediated dilation of the brachial artery and on central aortic pressure in diabetic patients with pre-hypertension or Stage 1 hypertension.

Detailed description

Patients are double-blind placebo-controlled randomized to either aliskiren or sugar pill/placebo. Effects on blood parameters and arteries are evaluated in both groups.

Conditions

• Diabetes
• Pre-hypertension
• Hypertension

Interventions

Type	Name	Description
DRUG	aliskiren 300 mg once daily	aliskiren 300 mg daily
DRUG	Placebo/sugar pill	Sugar pill/placebo

Timeline

• Start date: 2011-06-01
• Primary completion: 2012-01-01
• Completion: 2012-01-01
• First posted: 2011-05-06
• Last updated: 2017-05-11
• Results posted: 2014-06-30

Locations

1 site across 1 country: United States