NCT01348984

Study of Transdermal Fentanyl Patch to Treat Postoperative Pain in Total Knee Arthroplasty

Transdermal Fentanyl Patch for Postoperative Analgesia in Total Knee Arthroplasty

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Khon Kaen University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether transdermal fentanyl patch

Detailed description

Total knee arthroplasty (TKA) has severe postoperative pain that prevents mobilization of patient. The best standard analgesia regimen is patient-control analgesia (PCA) which requires a PCA pump that is expensive. Transdermal fentanyl patch (TFP)(50 mcg/hr) can release fentanyl into blood circulation at rate 50 mcg/hr for three days. It has slow onset of about 12-14 hours, so it's used to treat chronic pain, not popular for a cure of pain. If the investigators apply TFP at appropriate times, i.e. 12-14 hours before surgery, it may be used to treat acute postoperative pain. If it can give good analgesia for TKA, it can replace PCA. The benefit is that it is much cheaper and more convenient.

Conditions

• Postoperative Pain

Interventions

Type	Name	Description
DRUG	transdermal fentanyl patch	TFP = transdermal fentanyl patch (50 microgram/hour)
DRUG	placebo patch	group 2 = placebo patch

Timeline

• Start date: 2010-04-01
• Primary completion: 2010-10-01
• Completion: 2010-12-01
• First posted: 2011-05-06
• Last updated: 2011-05-06

Locations

1 site across 1 country: Thailand