NCT01344941

Human Immune Responses Toward HIV-1 Envelope Antigens

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 8 (actual)
• Sponsor: St. Jude Children's Research Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The primary objectives of this study is to * Define the envelope-specific B-cell and T-cell responses in humans who have received a St. Jude HIV-1 vaccine. * Describe mechanisms of HIV-1 envelope processing and consequent B-cell and T-cell activities.

Detailed description

The goal of this protocol is to understand how human lymphocytes respond to HIV-1 antigens in the context of vaccination or infection. This protocol will support understanding of the immune response by providing a source of lymphocytes and serum from selected individuals to study in laboratory based investigations. Blood samples from individuals who have received an HIV-1 vaccine, individuals who are HIV-1-infected, and individuals who are HIV-1-uninfected are requested to: (1) test previously vaccinated volunteers for HIV-1 envelope-specific B-cell and T-cell immune activities, and (2) increase understanding of how the human immune system processes and responds to HIV-1 envelope proteins.

Conditions

• HIV Infection

Timeline

• Start date: 2010-03-01
• Primary completion: 2015-11-01
• Completion: 2015-11-01
• First posted: 2011-04-29
• Last updated: 2015-11-05

Locations

1 site across 1 country: United States