Trials / Completed
CompletedNCT01342783
Biomarkers in Samples From Young Patients With Soft Tissue Sarcoma
Next Generation Sequencing of Childhood Soft Tissue Sarcomas to Identify Drivers of Primary and Metastatic Disease
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 20 (estimated)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research trial is studying biomarkers in samples from young patients with soft tissue sarcoma.
Detailed description
OBJECTIVES: * To identify the key components of driver pathways of primary and secondary soft tissue sarcomas. * To perform the next-generation sequencing on primary versus normal on undifferentiated sarcomas. OUTLINE: Genomic DNA and RNA samples from undifferentiated sarcoma tumors are analyzed by next-generation sequencing for somatic mutations. Normal matched lymphocytes and tissue are also analyzed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | DNA analysis | |
| GENETIC | RNA analysis | |
| GENETIC | mutation analysis | |
| GENETIC | nucleic acid sequencing | |
| OTHER | laboratory biomarker analysis |
Timeline
- Start date
- 2011-05-01
- Primary completion
- 2016-05-01
- First posted
- 2011-04-27
- Last updated
- 2016-05-18
Source: ClinicalTrials.gov record NCT01342783. Inclusion in this directory is not an endorsement.