NCT01341535

Comparison of Adaptive Dose Painting by Numbers With Standard Radiotherapy for Head and Neck Cancer.

A Two-arm Phase II Randomized Study, Comparing Adaptive Biological Imaging - Voxel Intensity - Based Radiotherapy (Adaptive Dose Escalation) Versus Standard Radiotherapy for Head and Neck Cancer.

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: University Hospital, Ghent · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators hypothesize that treatment adaptation to biological and anatomical changes, occurring during treatment, can increase the chance of cure at minimized or equal radiation-induced toxicity in head and neck cancer patients. This trial compares standard intensity-modulated radiotherapy (IMRT), using only pre-treatment planning 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography to adaptive 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography voxel intensity based IMRT or volumetric-modulated arc therapy (VMAT) using repetitive per-treatment planning 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography for head and neck cancer.

Conditions

• Primary Non-operated Squamous Cell Carcinoma of Oral Cavity
• Primary Non-operated Squamous Cell Carcinoma of Oropharynx
• Primary Non-operated Squamous Cell Carcinoma of Hypopharynx
• Primary Non-operated Squamous Cell Carcinoma of Larynx

Interventions

Type	Name	Description
RADIATION	Adaptive dose-painting-by-numbers	Adaptive dose escalation by dose-painting-by-numbers.
RADIATION	standard intensity-modulated radiotherapy (IMRT)	Standard radiotherapy for head and neck cancer.

Timeline

• Start date: 2011-09-01
• Primary completion: 2017-10-31
• Completion: 2021-07-15
• First posted: 2011-04-25
• Last updated: 2022-12-14

Locations

2 sites across 1 country: Belgium