Trials / Completed
CompletedNCT01338311
Salbutamol Tolerance Onset
Salbutamol: Tolerance to Bronchoprotection vs. Methacholine: Time Course of Onset
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 15 (actual)
- Sponsor
- University of Saskatchewan · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
Overuse of inhaled bronchodilator beta agonist medication results in a loss of effectiveness (i.e. tolerance). This has been shown for the short acting beta agonist salbutamol and the long acting beta agonist salmeterol. Tolerance to salmeterol is present within 24 hours. The onset of tolerance to salbutamol is not known.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | salbutamol | 200mcg twice daily for a total of 7 doses |
| DRUG | Placebo | 200mcg twice a day for a total of 7 doses (3.5 days). |
Timeline
- Start date
- 2011-03-01
- Primary completion
- 2012-03-01
- Completion
- 2012-03-01
- First posted
- 2011-04-19
- Last updated
- 2012-07-20
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT01338311. Inclusion in this directory is not an endorsement.