Clinical Trials Directory

Trials / Completed

CompletedNCT01336881

Biomarkers in Tissue Samples From Young Patients With Liver Cancer

Genetics and Biology of Liver Tumorigenesis in Children

Status
Completed
Phase
—
Study type
Observational
Enrollment
99 (estimated)
Sponsor
Children's Oncology Group · Network
Sex
All
Age
16 Years
Healthy volunteers
Not accepted

Summary

This research trial is studying biomarkers in tissue samples from young patients with liver cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

Detailed description

PRIMARY OBJECTIVES: I. To identify biomarker signatures associated with hepatoblastoma subtypes (by microRNA array profiling), and their potential correlation with liver developmental stages as well as outcome. II. To correlate expression array data with copy number array data. SECONDARY OBJECTIVES: I. To carry out a focused sequencing interrogation of amplified or deleted genomic regions as well as genes in key cell pathways involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma. II. To perform whole exome sequencing in a subset of tumors. OUTLINE: This is a multicenter study. Archived tumor tissue samples are analyzed for hepatoblastoma and other liver tumor biomarkers by microRNA array profiling and exome sequencing. Results are then compared with patients' clinical data.

Conditions

Interventions

TypeNameDescription
GENETICRNA analysis
GENETICgene expression analysis
GENETICmicroarray analysis
GENETICnucleic acid sequencing
OTHERdiagnostic laboratory biomarker analysis

Timeline

Start date
2011-04-01
Primary completion
2011-07-01
First posted
2011-04-18
Last updated
2016-05-18

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT01336881. Inclusion in this directory is not an endorsement.