NCT01334008

Study of Circulating Tumoral DNA in Metastatic Choroidal Melanoma

Development and Validation of a Circulating Tumor DNA Detection Technique in Patients With Metastatic Choroidal Melanoma

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Institut Curie · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Circulating tumor DNA detection and quantification in patients with metastatic choroidal melanoma.

Detailed description

Technique development: In first step, the different available techniques will be evaluated for specificity and sensibility using serial dilutions of cell lines with or without GNAQ mutation. Validation: The tumor DNA detection rate will be estimated from metastatic uveal patient's blood. The investigators will study 40 patients to obtain at least 15 patients bearing a GNAQ mutation in the primitive tumor or in metastasis. With those 15 patients, the investigators will determinate the most sensitive technique and the best cost/efficiency ratio.

Conditions

• Choroidal Melanoma, Diffuse

Interventions

Type	Name	Description
BIOLOGICAL	Blood sampling	30ml of patient peripherical blood will be collected

Timeline

• Start date: 2011-04-01
• Primary completion: 2012-02-01
• Completion: 2012-05-01
• First posted: 2011-04-12
• Last updated: 2025-11-24

Locations

1 site across 1 country: France