NCT01327144

Efficacy of Oral Famciclovir Versus Aciclovir Treatment in Patients With Herpes Zoster

A Prospective, Randomized, Multicenter Study of the Efficacy and Safety of Famciclovir 500 mg Comparing To Aciclovir 400mg in Patients With Herpes Zoster

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 177 (actual)
• Sponsor: EMS · Industry
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Herpes Zoster is an infection that affects part of the nervous system caused by Varicella Zoster Virus. Herpes Zoster manifests as vesicular eruption in the dermatome, often associated with significant pain. There are effective oral prescription antiviral medicines available to reduce the discomfort of symptoms as famciclovir and aciclovir. This is a phase III, multicenter, randomized, parallel-group study to compare the efficacy and safety of treatment with Famciclovir (500 mg) comparing to Aciclovir (400 mg) in patients with Herpes Zoster.

Detailed description

Study Design * single blind study, prospective, parallel group, intent to treat trial * Experiment duration: 7 days * 2 visits (days 0, and 7) * Reduction of symptoms * Adverse events evaluation

Conditions

• Herpes Zoster

Interventions

Type	Name	Description
DRUG	Famciclovir	Famciclovir 500 mg- 1 tablet each 12 hours for 7 days
DRUG	Aciclovir	Aciclovir 400 mg- 02 tablets each 4 hours for 7 days

Timeline

• Start date: 2012-06-01
• Primary completion: 2017-05-01
• Completion: 2017-07-01
• First posted: 2011-04-01
• Last updated: 2019-04-17

Locations

5 sites across 1 country: Brazil