NCT01326650

Vitamin D and Mortality in Heart Failure

Effect of Vitamin D on All-cause Mortality in Heart Failure Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 400 (actual)
• Sponsor: Heart and Diabetes Center North-Rhine Westfalia · Academic / Other
• Sex: All
• Age: 18 Years – 79 Years
• Healthy volunteers: Not accepted

Summary

Despite significant therapeutic improvements, congestive heart failure (CHF) patients still have a poor prognosis. Currently, 5-year survival rates are only 35-50%. There is an accumulating body of evidence from prospective cohort studies that low circulating 25-hydroxyvitamin D is an independent predictor of all-cause and cardiovascular mortality, respectively. Vitamin D deficiency is prevalent among CHF patients. We hypothesize that vitamin D may improve survival in CHF patients. We therefore aimed to investigate whether vitamin D supplementation reduces mortality and increases event-free survival in end-stage CHF patients.

Conditions

• Congestive Heart Failure

Interventions

Type	Name	Description
DRUG	Vitamin D	daily oral vitamin D supplement of 100 micrograms for three years
DRUG	placebo	daily oral placebo supplement for three years

Timeline

• Start date: 2010-11-01
• Primary completion: 2016-07-01
• Completion: 2016-07-01
• First posted: 2011-03-31
• Last updated: 2016-08-11

Locations

1 site across 1 country: Germany