NCT01326520

Effect of Dietary Phospholipids on Atopic Dermatitis

Effect of Dietary Milk Phospholipids on Subjects With Atopic Dermatitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 39 (actual)
• Sponsor: University of Jena · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to investigate the influence of a milk phospholipid enriched dairy product on subjects with atopic dermatitis determining parameters of the immune status, the plasma lipid profile and the skin texture.

Detailed description

Based on the facts, that on the one hand milk phospholipids are characterized by a high sphingolipid content and on the other hand a disturbed sphingolipid metabolism in the epidermis of patients with atopic dermatitis was verified, a double blinded, controlled, randomized, cross-over study with a daily supplementation of 3 g milk phospholipids to subjects with a mild to moderate atopic dermatitis will be conducted. Forty patients will be randomized between two groups of each 20 patients. After an individual checkup and a run-in period of 2 weeks, the one group will receive the phospholipid enriched dairy product and the second group will be given a placebo dairy product over two month. A wash out-period of 4 weeks will follow, and the patients will consume the contrary dairy products over two month after a 2-week run-in period again.

Conditions

• Dermatitis, Atopic

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	milk phospholipid	The patients will consume daily 250 mL of a dairy product, which is enriched with 3 g of milk phospholipids.
DIETARY_SUPPLEMENT	diary product	The patients will consume daily 250 mL of a common dairy product.

Timeline

• Start date: 2011-03-01
• Primary completion: 2011-10-01
• Completion: 2011-10-01
• First posted: 2011-03-31
• Last updated: 2012-06-20

Locations

1 site across 1 country: Germany