Trials / Completed
CompletedNCT01323894
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling/Hydroxyapatite Nanoparticles--Comparisons Between Non-viral and Viral Administration in Tissue Engineered Bone Regeneration
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 3 (actual)
- Sponsor
- China Medical University Hospital · Academic / Other
- Sex
- All
- Age
- 10 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The first year purpose: The best concentration of canonical Wnt3a will be investigated in promoting the osteoblastogenesis of human mesenchymal stem cells.
Detailed description
Our previous work is investigating the viral (Adv-BMP-2) administration for the development of a model to generate bones for possible use in clinical settings; the non-viral and viral administrations will be compared for best osteogenesis effects. The first year purpose: The best concentration of canonical Wnt3a will be investigated in promoting the osteoblastogenesis of human mesenchymal stem cells.
Conditions
Timeline
- Start date
- 2011-08-01
- Primary completion
- 2012-08-01
- Completion
- 2013-07-01
- First posted
- 2011-03-28
- Last updated
- 2016-06-17
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT01323894. Inclusion in this directory is not an endorsement.