NCT01321801

Pregabalin and Analgesia After Laparoscopic Cholecystectomy

Preoperative Use of Pregabalin and Analgesia Levels After Laparoscopic Cholecystectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Larissa University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate how effective is the preoperative administration of pregabalin 600mg, to attenuate postoperative pain and opioids consumption after laparoscopic cholecystectomy.

Detailed description

Acute pain frequently occurs during the postoperative period.Not treated acute postoperative pain may predict the development of chronic pain.Recently, the analgesic effect of pregabalin, as a part of a multimodal analgesia, has been evaluated in many studies. They have shown that pregabalin may have a role in the post operative pain management, as an adjunct. Pregabalin is an anticonvulsant and anxiolytic drug, which have a more favorable pharmacokinetic profile from its predecessor gabapentin. Acute postoperative pain after laparoscopic cholecystectomy is complex in nature. Postoperative pain is the main complaint and the primary reason for delay discharge after laparoscopic cholecystectomy.The study includes patients undergoing laparoscopic cholecystectomy.

Conditions

• Pain Postoperative

Interventions

Type	Name	Description
DRUG	Pregabalin	Preoperative administration of pregabalin 600mg
DRUG	placebo	Preoperative administration of a matching placebo

Timeline

• Start date: 2009-11-01
• Primary completion: 2010-10-01
• Completion: 2010-12-01
• First posted: 2011-03-24
• Last updated: 2013-01-29

Locations

1 site across 1 country: Greece